I guess it would be considered a cancer in terms of creativity and plot.
If the moe doesn't detract from the plot or the anime as a whole, e.g. entire episodes that aim to please the fans, then I wouldn't mind it. Sadly, it happens quite often, often enough for animes to be labeled as a "moe anime". I'd prefer to see moe as a crutch that is used occasionally to boost sales, than to see moe as the whole story.
To answer the question, I would rather see original stories that may or may not be good because: 1. They tried and 2. It's refreshing.
---------------------------------

Originally Posted by
solidoxygen
...isn't it incredibly lazy to just pump out cute girls instead of making interesting shows with good settings, plot, and characterization...
You're right, it is lazy, lazy and profitable. Anime production companies cannot afford to be otherwise, which is why there is moe, moe everywhere.
Although, that is pretty much common knowledge, so the following won't be anything new.
Moe is an important element in the "guaranteed formula". An anime's success, in Japan at least, is heavily based on its Blu-ray and DVD sales. I've looked at Blu-ray sales rankings in Japan, and found that a majority of the top 20 sales are moe animes. It makes sense why there will always be a cute girl doing cute things in every anime season airing.
Anime with good plot, settings, and characterization come out every once in a while, though. It is better than never haha.
---------------------------------

Originally Posted by
solidoxygen
...The fact that anime continues to consistently about little girls makes it hard to ever expand outward to the general public like Disney has.
Miyazaki makes movies that the entire family can enjoy while shows like Yuru Yuri would never, ever appeal to a grown audience.
In terms of appealing to the general public, moe (obviously) cannot provide that since it is already targeting a small niche (that is ready to fork over their money). Disney animations/cartoons appeal to the general audience because it targets the general audience.
However, just because moe shows are prevalent doesn't mean all of anime are like moe shows. The same can be said about cartoons. Just because Disney targets a large audience doesn't mean all of cartoons are like Disney. Last time I checked, Bambi and Adventure Time, and K-ON! and Berserk are, in its entirety, different, and should not be compared.
If we factor out moe shows and Disney from the equation, what's left? For cartoons, shows like Adventure Time, Spongebob, and comic book adaptations are rampant, while only a few diamonds in the rough like The Avatar are known. As for anime, if you take moe shows out of the equation *cough*andharemandecchiandmainstreamshows*cough*, you are left with Hayao Miyazaki films, and many shows that provoke thought and various emotions.
Anyways, despite all the moe *cough*andharemandecchiandmainstreamshows*cough*, anime still seems more palatable than cartoons, and targets a wider audience.
Besides, Disney is only able to expand outward to the general public because Disney has a huge presence, and a lot of power, backed by a lot of money. I haven't seen anything amazing from Disney in a long, long while. (Pixar doesn't count.)